SURGERY RESEARCH INSIGHT

Winter 2022

Published Dec 20, 2022 by
Filed under:
2022 YEAR IN REVIEW

SPOTLIGHT

Surgery and Translational Research 

Translational Research applies laboratory approaches and discoveries to clinical problems and leads to advances in new drugs, assays, devices, interventions, and training (“bench-to-bedside”).

Currently, two of three surgery involved extramurally funded translational research projects are in Surgical Oncology are investigating immune responses to cancer. Both projects have the potential to impact the patients served by ECU surgeons and ECU Health.

Dr. Vohra (PI), Dr. Verbanac (Co-I), Dr. Ghosh and other collaborators are funded by the American Cancer Society to study sentinel node immune signatures and outcome in Triple Negative Breast Cancer. The overall hypothesis is that the sentinel node immune signature will provide clinically meaningful information that can be used to guide immunotherapy approaches. Preliminary data for this study (generated using RNA isolated as part of an early, prospective ECU-based breast cancer multicenter sentinel node trial) found that T helper cell and dendritic cell immune signatures in negative nodes were associated with risk of recurrence and disease-free survival. Transcriptome and immunohistochemical analysis of tumor-node pairs from FFPE patient blocks is underway in this expanded study.

In 2022, Dr. Nasreen Vohra and Dr. Fisher-Wellman (Co-PI in Physiology/ECDOI) received a 2-year award from the Department of Defense to study Anticancer Immunity in patients with melanoma. An emergent ‘targeted’ treatment approach involves the use of immune checkpoint inhibitors (e.g., anti PD-1/PD-L1 therapy) that work by bolstering the body’s own anti-tumor immunity. Although immune checkpoint inhibitors have shown remarkable efficacy, a substantial portion of patients fail to respond. A growing body of evidence causally links immune cell failure to disruptions in the cell’s major energy producing organelles – mitochondria. This project investigates differences in immune cell mitochondria in the context of anti-melanoma immunity. The short-term goal of this application is to identify immune-specific drug targets such that, in the long-term, patients diagnosed with melanoma can be afforded more effective immune therapies.  Analysis of tumor-infiltrating cells and circulating immune cells from patients enrolled in this prospective, IRB-approved study is underway.

General/Bariatric Surgery is involved with the MetFlex (Metabolic inflexibility is related to elevated muscle anaerobic glycolysis NIH DK120296) study in collaboration with the Department of Physiology, including Dr. Joseph Houmard (Co-PI), Dr. G. Lynis Dohm (Co-PI), Dr. Walter Pories (Co-I), Dr. Terry Jones (Co-I), Dr. Eric DeMaria (Co-I), and Dr. Nick Broskey (Co-I). This NIH funded study began July 1, 2019, and is currently completing year three of five, with a budget of $2,195,564.

The title of the NIH funded MetFlex study is “Metabolic inflexibility is related to elevated muscle anaerobic glycolysis”.  The main focus of the study is on overweight subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases.  We hypothesize that in some overweight individuals there is a “metabolic program” in skeletal muscle which predisposes them to the development of obesity.  A second goal is to investigate if metabolic surgery, which is known to reverse metabolic diseases, changes the muscle metabolic program.  Findings from this study may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Upcoming Absract Deadlines
ConferenceAbstract Deadline
Society of Critical Care Medicine - Critical Care CongressThursday, August 1 @ 12 pm CST
Academic Surgical CongressFriday, August 9 @ 11:59 PM EDT 
American Venous Forum Friday, August 9 @ 5 pm EDT
Western Trauma AssociationMonday, September 2
Southern Association for Vascular SurgeryTuesday, September 3, @ 11:59 pm EDT
American Society of Transplant Surgeons (ASTS)Monday, September 9 @ 5 pm EDT
Society for Clinical Vascular Surgery (SCVS)Monday, September 9 @ 11:59 pm EDT
Society of American Gastrointestinal & Endoscopic Surgeons (SAGES)Friday, September 20 @ 11:59 pm PDT
ASCO Gastrointestinal Cancers SymposiumTuesday, September 24 @ 11:59 PM EDT
Society of Surgical Oncology (Annual Meeting) Monday, October 7
ECU Health Quality Improvement SymposiumMonday, October 14
American Society of Colon & Rectal Surgeons (ASCRS)Tuesday October 15 @ 11:59 PM EDT
Society of Surgical Oncology (ACT)Wednesday, October 16, 11:59 CST
Association for Surgical Education (ASE)gWednesday, October 30 @ 5 pm EDT
General Thoracic Surgical ClubFriday, December 6
Upcoming Conferences
ConferenceConference DatesLocation
Safe States August 20, 2024 Portland, OR
NC/SC - American College of Surgeons (ACS)- Annual Meeting August 23, 2024 Isle of Palms, SC
American Association for the Surgery of Trauma (AAST)(TACS) September 11, 2024 Las Vegas, NV 
Society of Black Academic Surgeons (SBAS) September 19, 2024 Davis, CA
American Society of Plastic Surgeons (ASPS) September 26, 2024 San Diego, CA
American Academy of Pediatrics (AAP) September 27, 2024 Orlando, FL
CHEST Annual MeetingOctober 6, 2024Boston, MA
Association of Women Surgeons (AWS)October 18, 2024San Francisco, CA
American College of Surgeons (ACS)October 19, 2024San Francisco, CA
Surgical Outcomes Club (SOC)October 19, 2024San Francisco, CA
Patient Centered Outcomes Research Institute (PCORI)October 22, 2024Washington, D.C.
Kidney Week (ASN)October 23, 2024San Diego, CA
Society of Immunotherapy of Cancer (SITC)November 6, 2024Houston, TX
ACS TQIPNovember 12, 2024Denver, CO
Southern Surgical Association (SSA)December 8, 2024Palm Beach, FL
National Research Conference for the Prevention of Firearm Related HarmsDecember 9, 2024Seattle, WA
San Antonio Breast Cancer SymposiumDecember, 10, 2024San Antonio, TX
Division Updates

Advancing Medical Science in Surgical Disparities

(SEI)Surgical Equity Index

Despite immense attention directed to the public health priority of disparities in access to surgical care, reducing these disparities has been a particularly vexing issue.  Access, defined as “the timely use of personal health services to achieve the best possible health outcomes”, continues to be a major challenge in the United States and remains a priority of the Healthy People 2023 initiative.  Personal health services may include access to surgical services in a substantial proportion of the population.  Surgical access is influenced by the complex interaction of numerous factors including race/ethnicity, social economic status (SES), insurance, and even the willingness to undergo surgery while outcomes and access maybe influenced by disparities in disease burden and co-morbid conditions, surgeon volume, and hospital volume all of which may result in surgical health care disparities.  However, limited access to health care is closely associated with surgical health care disparities. The American College of Surgeons Committee on Health Care Disparities states “there is no quality without access”.

Current strategies to understand, reduce, and/or eliminate disparities in access to surgical care, to date, have been disappointing.  These approaches utilize traditional quantitative analytic techniques which typically rely on strict assumptions of independence, linearity, and quantitating the contribution of individual factors using regression techniques to detect surgical disparities.  The results are largely descriptive and fail to address mechanisms that may explained why observed disparities occur.  Most importantly, however, is that these analytic approaches fail to consider the dynamic interactions of multiple pathways at multiple levels that characterize complex systems and that simultaneously contribute to disparities in access to surgical cancer care.  Additionally, these research strategies do not have a validated metric to identify and quantify a disparity and to ultimately ascertain progress or success in reducing disparities.  There is a critical need to identify unrecognized patterns, correlations, and non-linear relationships and identify key leverage points and pathways which result in disparities in access to surgical care.

To address this critical need, the Division of Surgical Research has adopted a disparities research framework described by Kilbourne and colleagues of detecting, understanding, and ultimately reducing disparities in access to surgical care.  We have described a quantitative methodology which defines vulnerable populations and identifies potential disparities in surgical access which we have termed the surgical equity index (SEI) and populated a robust data platform that will allow us to apply big data analytics, machine learning, and complex system science approaches to understanding the dynamic interrelationships between patient, provider, healthcare systems, social relationships, physical environment, and social conditions and policies that will lead to evidence-based interventions.  Our long-term goal is to identify and model intervention(s) that are predicted to have the greatest efficacy in reducing disparities in access to surgical cancer care and develop novel informed interventions to mitigate these disparities.

A Pivotal Phase 3 Trial to Evaluate the Safety and Efficacy of Clazakizumab for the Treatment of Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients (IMAGINE)

A major milestone for the Division of Surgical Research and Division of Surgical Immunology and Transplantation at ECU was reached in December 2022. This site was selected for enrollment in an interventional drug trial. This trial investigates the efficacy and safety of clazakizumab [an anti-interleukin (IL)-6 monoclonal antibody (mAb)] for the treatment of CABMR in recipients of a kidney transplant. This randomized double-blinded trial has two arms inclusive of either a placebo consisiting of physiologic saline solution that is administered subcutaneously and no treatment of CABMR for 5.5 years or clazakizumab is a genetically engineered humanized immunoglobulin G1 (IgG1) mAb that binds to human IL-6 that is administered subcutaneously. The primary endpoint is defined as time to all-cause composite allograft loss. 

The study start-up will commence in 2023. Drs. David Leeser and William Irish will serve as Co-Principal Investigators. The current end date will be 2030. 

IMAGINE

  • Investigator Initiated Kidney Cancer Research at ECU Health Medical Center

    The study titled “Graft Survival and Function of Transplant Patients at East Carolina University” is intended to do exactly what the title says. In summary, the study goal is to monitor the renal function of kidney transplant recipients as well as incidence of rejection, infections, and cancer.

    Investigators: Lorita Rebellato-de Vente, Dr. Carl Haisch and Dr. William Irish

    1. Aim: Transplant recipients have a 2-4 fold increased risk of developing malignancies over the general population. Cancer is the second most common cause of death for recipients. In order to obtain a more comprehensive incidence of cancer in transplant recipients, we requested cancer data from the State of North Carolina Center for Health Statistics.  
    2. Public Health Benefit: This study will provide important information about the long-term risks for cancer development in our patient population since kidney transplant recipients have a significantly increased risk of malignancy compared to the general population. The increased risk is attributed to the need for chronic immunosuppression that is required to preserve graft function. Increased occurrence of cancer has been one of the main medical burdens in transplant recipients.   
    3. Project Description: We requested cancer data from recipients that received a kidney or kidney/pancreas transplant between 01/01/1995 to 12/31/2020. Data analysis will be performed soon. An abstract will be submitted to the American Society of Transplantation to be presented in the 2023 meeting. In addition, a summary of the findings will be submitted for publication.    
    4. Project Significance: It is important that patients and their providers be aware of the cancer risks associated with transplantation. Each patient should be properly screened and receive medical management after transplantation.  

    Team Recognized as High Enrolling Site

     

    Congratulations to team’s research specialist Peyton Garris and transplant team for achieving our site’s enrollment goal for the ProActive – The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry.

    Due to her excellent recruiting skills, she has garnered ECU transplant research national attention as a top enrolling site back-to-back months with ECU being the 2nd highest enrolling site for November and 6th overall in the country out of 52 sites for TRULO – TruGraf Long-term clinical Outcomes Registry.

    Peyton’s hard work continues to help grow the research efforts for our department. These sponsors have reached out for more enrollment and increase in budgets due to her timely data entry and high recruitment and retention.

     

     

2022 Faculty and Staff Updates

Dr. Kathryn VerbanacKathryn M. Verbanac

As of November 1, 2022, Dr. Kathryn Verbanac returned to the department as professor in the Division of Surgical Oncology after completing her administrative role as assistant vice chancellor of research development in REDE.  She will be splitting her time with the Division of Surgical Research and will serve as Director of the North Carolina Tissue Consortium.  She conducts translational cancer research from the perspective of a biochemist and immunologist.  She has also been heavily involved in institutional efforts to increase student and faculty diversity in STEM and biomedical research, including being one of the ECU Multi-PIs on an extramural Faculty Institutional Recruitment for Sustainable Transformation (FIRST) U54 grant submission that is under NIH review

Dr. Debjani Ghosh

Dr. Debjani Ghosh has joined the Department of Surgery in the Surgical Oncology Division in August 2022 as a Research Specialist. Dr. Ghosh earned her PhD degree from India. She worked at University of Missouri at Columbia, initially as post-doctoral fellow with extensive training in molecular biology and finished her work as Research Assistant Professor. Due to funding crunch, she moved to Harvard Medical School, Beth Israel Deaconess Medical Center at Boston and worked as T32 trainee on Lupus autoimmune disease.  From Harvard, she joined East Carolina University and worked initially as fellow and later research instructor and developed IFN beta mediated vaccine to cure autoimmune disease of multiple sclerosis. Currently, she is working on sentinel node immune signature and outcome in triple negative breast cancer with Dr. Vohra and Dr. Verbanac. She is also involved in active research project entitled “Bioenergetic characterization of solid tumors and primary leukemias” and “Sentinel node immune signatures and outcome in stage II melanoma cancer” with Dr. Vohra and in collaboration with Dr. Kelsey Fisher-Wellman, Assistant Professor of Department of Physiology

Moses McDaniel

In May 2022, Moses McDaniel rejoined the Division of Surgical Oncology as a Research Specialist. He is the coordinator for the North Carolina Tissue Consortium for ECU. He is a native son of Eastern NC hailing from Halifax County, specifically Enfield, NC. He has earned a Bachelor of Science degree in Biology with a Minor in Biotechnology from Elizabeth City State University and a Master of Science degree in Biology from North Carolina Central University. He is currently in a Doctor of Health Science program at Campbell University.  Professionally he aims to join ECU in the ongoing struggle of addressing Health Disparities in Eastern North Carolina and to increase minority participation in all aspects of research.  

Fun fact he considers himself an amateur entomologist. However not only in collecting specimens, but also researching and studying insects for micro molecules that can potentially fight cancer.  

North Carolina Tissue Consortium | Brody School of Medicine | ECU 

Crystal Harris

Crystal Harris, started in May of 2022 as an Administrative Support Specialist, for the Division of Surgical Research. She is located at the front desk area of our new office location, BSOM 4S-10 Suite. Crystal has administrative, medical, and customer service, experience that supports our team and mission.

She can be reached Monday – Friday 8:00 am -5:00 pm at harriscr21@ecu.edu or 252-744-5292.

Crystal has lived in Eastern NC her entire life, and resides with her husband (Jason), three sons (Christian, Andrew and Kole), two cats (Sugar Pie and Grace), dog (Lolly), and two hamsters (Swervo and Juice).  She enjoys learning all the responsibilities of her new role here in the Department of Surgery, spending time with her family, and making new friends.

Operational Updates

NIH Requirement for Data Management Plan Updates coming in 2023

The NIH has issued a Data Management and Sharing (DMS) policy, effective January 25, 2023, to promote the sharing of scientific data. Specifically, regarding Human Data Sharing, the NIH’s mission is to improve the health of the public through support of biomedical research and the training of biomedical scientists. To further advance and accelerate research to benefit the public health, data developed in the NIH Intramural Research Program (IRP) should be collected in a manner that permits and promotes the broadest sharing possible. Data sharing may be complicated or limited, in certain cases, by agreements with outside collaborators, e.g., Clinical Research and Development Agreements (CRADAs) or Clinical Trial Agreements, by Institutional Review Board (IRB) rules or by other constraints. NIH IRP investigators should share data broadly for secondary research purposes, in all cases consistent with applicable laws, regulations and policies.

ECU DMP tools

DMP Builder 

Data Management Plan Template

UPDATED FORM ALERT

The subrecipient Letter of Intent form template has been updated. Revised language that more clearly articulates the attestation for subrecipients that have a PHS-compliant FCOI policy has been added. The updated template can be found at its home base page:

https://rede.ecu.edu/ora/ecu-subrecipient-letter-of-intent/.

If you’re working from a downloaded copy, please update your downloaded copy with the latest version!

Faculty can Receive Support to Publish Open Access Through: Open Access Phishing Support Fund

The Open Access Publishing Support Fund (OAPSF), sponsored by ECU Libraries, is available to help with article processing and open access charges for open access publishing. We welcome applications from current faculty, staff, graduate students, postdoctoral scholars or resident physicians. 

Spring applications will be accepted until April 15, 2023. Applications will be reviewed shortly after the deadline.

For more information about the OAPSF and to apply, please visit: go.ecu.edu/openaccess.

For additional information and support for open access publishing, visit our Sustainable Scholarship website: https://sustainablescholarship.ecu.edu/.

QUESTIONS? Please contact us at scholarlycomm@ecu.edu with any questions.

Regulatory Updates

Importance of Research to Maintain Level 1 Trauma ACS Accreditation

As our site prepares for a site visit early in 2024, it is important to understand the research and scholarly activities required to maintain a Level 1 Trauma Center that services eastern North Carolina. See the ongoing ACS Level 1 trauma research requirement list below:

Level I trauma centers must demonstrate the following scholarly activities during the verification cycle:

  • At least 10 trauma-related research articles*
  • At least three articles must be authored by general surgery/pediatric trauma providers
  • Research activity must be performed at the trauma center
  • If case series are to be counted, they must include more than five patients
  • Basic science research must involve topics directly related to the pathophysiology of injury
  • At least three articles must be from disciplines other than general/pediatric surgery
  • All articles must be published or accepted for publication in peer-reviewed and indexed journals
  • Authors from the trauma center must meet accepted authorship requirements of the International Committee of Medical Journal Editors
  • One paper from acute care surgery may be included.

Participation by at least one trauma program faculty member as a visiting professor, invited lecturer, or speaker at a regional, national, or international trauma conference

Support of residents or fellows in any of the following scholarly activities: laboratory experiences; clinical trials; resident trauma paper competitions at the state, regional, or national level; and other resident trauma research presentations

Process Change Memo 12/2/2022: CRG pricing process

Going forward, we are going to change the process for receiving pricing from CRG in Study Startup. If your study will involve the health system for services, procedures, and/or treatment, please email crg.ancillary@vidanthealth.com and Abner Abner.MarriagaCastillo@Vidanthealth.com while preparing your IRB application once your have your SRF drafted.  Please also attach a copy of the study protocol.

Please use the following template email:

Subject: New Study Pricing Request [UMCIRB #]

Body of message:

Study Title: [Short title is fine]

UMC IRB #: [Should match ePirate]

PI: [Full name and Department]

Where will the study take place: [Outpatient, Inpatient, or Mix (for studies where patient may receive treatment in ECU Health Day Hospitals)]

If “Inpatient” or “Mix” – a protocol breakdown will be scheduled.

If “Inpatient” or “Mix” – please provide target MM/YY of SIV (if industry) or first enrollment (if not industry)

ECU Health Engagement: [Vendor for Labs / Imagining, Treatment (Hospital Pharmacy would be responsible for drug/device), or Other]

           Please list any unusual tests / procedures in email. Please also consult the CPT code book on the CTO intranet when finalizing your SRF to ensure you are using a code that hospital has in their system.

Type of Study: [Industry sponsored, Federally Funded (medicare rates would apply), Cooperative Group, or Other]

Please be sure to attach a copy of the draft SRF and protocol to your price request email. CRG uses these to verify that they are just a lab / imagining vendor and not responsible for other aspects of the study.

We are trying to find ways to expedite the study startup process. For example, with this new workflow, CRG would no longer perform a protocol breakdown for outpatient studies where they are only a vendor for lab work. Please let me know if you have any questions or concerns.

Thank you,

Cierra Buckman, MHS

Interim Director, Clinical Trials Office

Director of Research Administration, Department of Pediatrics

ECU Brody School of Medicine

2022 Resident Updates

CONGRATULATIONS to our Residents on their abstract submissions, presentations, education advancements and awards accomplished in 2022!

 

Abstract Submissions:

  1. Dec 2022: Seth Quinn’s, MD submission Ketamine for pre-hospital analgesia and sedation in the trauma population: a narrative review has been accepted for publication in SN Comprehensive Clinical Medicine
  2. Nov 2022: Hao S,Parikh A, Snyder R. Defining socioeconomic disadvantage: Geography and context matter [published online ahead of print, 2022 Nov 3]. J Surg Oncol. 2022;10.1002/jso.27127. doi:10.1002/jso.27127
  3. Hao S, Meyer DB, Klose C, Irish W, Honaker MD. Association of Distance Traveled on Receipt of Surgery in Patients with Locally Advanced Rectal Cancer. Accepted for publication in the International Journal of Colorectal Disease.
  4. The Road Less Traveled: Transportation Barriers to Cancer Care Delivery in the Rural Patient Population Ashley N. Wercholuk, Alexander A. Parikh, and Rebecca A. Snyder JCO Oncology Practice 2022 18:9, 652-662

Presentations

Upcoming: Hao MD Bridges L, Kennamer K, Honaker MD. Infectious Complications After Modified Stomal Purse-string Closure. Accepted for Quickshot podium presentation at the upcoming 18th Annual Academic Surgical Congress (Feb 7-9, 2023 in Houston TX)

Upcoming: Josh Aldridge, MD to present “A STATEWIDE ANALYSIS OF PREDICTORS OF TRAUMA CENTER TRANSFER: THE BURDEN OF NON-CLINICAL FACTORS” as a short oral presentation at the SESC 2023 Annual Meeting, February 11–14.

Oct 2022: Ashley Quinn, MD went to ACS Clinical Conference this past October to present her abstract on missed appointments in surgical oncology.

Oct 2022: Preston Bethea, MD Presented a video depiction of a per oral endoscopic excision of leiomyoma at the gastroesophageal junction.

The below video was presented at ACS Cardiothoracic Video Session (10/18/2022)

July 2022: Scarlett Hao, MD presented SDOH screening in ENC patients with cancer at the ACS Quality and Safety Conference.

Education:

May 2022: During her spare time, Dr. Hao earned her Master of Public Health from ECU!

Scholarships, Awards & Achievements:

Congrats to Caitlin Takahashi, MD who was accepted into the AOA (American Osteopathic Association) Training in Policy Studies (TIPS) Program!  Caitlin was accepted based on her leadership, passion for service and interest in making positive population-level change policy.

December 2022: Congrats to Brandon Peine, MD for receiving one of the 2023 STS Looking to the Future Resident Scholarships! This scholarship, sponsored by The Society of Thoracic Surgeons (STS) and its members, grants admission to the STS 59th Annual Meeting.

June 2022: Resident Awards Day:

May 2022: ECU Health Medical Center Staff GME Research Week Award Winners

Congrats to Seth and Tasos!

    • Educational Research & Innovation: Honorable Mention Poster: Resident Perception of Clinical Benefit and Educational Value of a Novel Low-Fidelity Simulation Curriculum: Anastasios Mitsakos, MD (General Surgery)
    • Clinical and Basic Science Research: Best Poster, Prospective Multi-Institutional Evaluation of the Use of Cholecystostomy: Seth Quinn, MD (General Surgery)

32nd Annual Department of Surgery – Resident Research Day

Congratulations to Winners!

    • Josh Aldridge, MD – A Statewide Analysis of Predictors of Trauma Center Transfer: The Burden of Non-Clinical Factors
    • Anastasios Mitsakos, MD – The Role of Institutional Growth and Maturation in Creating a Reliable Pancreatic Surgery Program

2023 Graduate Medical Education Research Week – Call for Oral and Poster Presentation Abstracts

ALL Abstracts Submission Deadline: Tuesday, February 14, 2023 – 5:00pm

The GME Office invites abstract submissions for oral and/or poster presentation at the 2023 ECU Health Medical Center Medical Staff Graduate Medical Education Research Week to be held: Tuesday, May 16 – Thursday, May 18, 2023.

Abstract submission categories are as follows:

Medical Education Initiatives (Program Director, Program Coordinator and faculty presenters only)

  • Educational Research & Innovation
  • Quality Improvement and Patient Safety
  • Clinical and Basic Science Research
  • Case Report with Literature Review

Please note that awards will be given in each submission category listed above, as well as for oral presentations.

Please see the attached Abstract Submission Form, as well as the Abstract Instructions and Submission Guidelines and other reference information, for further details.

Contact kelley.whitehurst@vidanthealth.com with any questions and your submissions.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

2022 Student Updates

First Division MPH Intern: Jacob Mitrious

This past summer was the inauguration of our MPH internship curriculum. Our first intern was Jacob Mitrious. He completed numerous projects to introduce him to the application of epidemiological theory in clinical research. He composed sample surveys that patients can fill out to help collect data for any necessary research. In addition, he collected data from past research articles to identify rates and trends of disparities among sample patients. Jacob also learned how to create an electronic data capturing system within REDCap. He shadowed the staff in the Department of Surgical Research to get a glimpse of what it’s like consenting patients and include them in current/future studies. He was introduced to regulatory through creating a sample IRB application. Currently, he is Social Clinical Research Assistant with the Internal Medicine/Pulmonary Department at Brody School of Medicine. He assists in clinical trials with this department which includes coordinating, consenting, data collecting and entering data into vendor specific sites and platforms. He is most interested in data collection and coordination as this position has taught me a lot about the field especially with clinical trials. He has career goals to continue with clinical trials and research including interventions among patients to improve health outcomes.

ASN Kidney Week, M4 Karen Kennamer Presented for ECU Transplant Team: Karen Kennamer (M4)

Abstract: Diagnostic Yield Among Patients With Diabetic Nephropathy and/or Hypertension: Genetic Testing in Kidney Transplant Waitlist Patients

Authors: David Leeser, MD, Karen Kennamer, Laurel Kartchner, Margaret Romine, MD, Ashley Aaron, MD, Kristel McLawhorn, MD, Heather Jones, MD, William Irish, MSc, PhD

Medical Students interested in surgical research

There is always a problem to solve. The mission of the Division of Surgical Research is to improve patient care, provide education in the pursuit of clinical and basic science investigations and health services research, and offer support to faculty, residents and students in the conduct, analysis and reporting of scientific inquiry.

If you are interested in getting involved in surgical research, there are a few basic steps you can initiate that will help expedite involvement in surgical research.

  1. Required Collaborative Institute Training Initiative (CITI) training:
      • All key research personnel must complete required CITI courses. For most research in this department, you must complete this module:
          • Group 1 – All Biomedical Investigators and Key Personnel: Medical, physiological or pharmacological studies that typically involve direct contact with participants. Includes, but is not limited to, research with drugs, devices or other interventions.

2. Registering for an ePirate account (PDF): Step by step instructions for registering your ePirate account and linking your CITI training modules.

Contact surgeryresearch@ecu.edu to provide a brief orientation and review of your research interest/s.

Study Updates

Surgical Research Clinical Trials

Currently Enrolling Studies

Area of StudyTitleTypeAccrualPIContact Info
Surg OncTransportation Barriers to Care in Rural Cancer PatientsObservationalDr. Drew HonakerStudy Coordinator
Kelly Martin
martinke21@ecu.edu
744-5723
Surg Onc/PancreasTrans Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy for Unresectable Locally Advanced Pancreatic CancerPhase II Trial11/12Dr. Emmanuel Zervos
Dr. Andrew Ju		Study Coordinator
Denise Brigham
brighamd@ecu.edu
744-4924
Surg Onc/PancreasComparing the Clinical Impact of Pancreatic Cyst Surveillance ProgramsInterventional3/10Dr. Emmanuel Zervos
Dr. Andrew Ju		Study Coordinator
Leslie Corbett
corbettl@ecu.edu
744-0456
Surg Onc/Soft TissueA Phase III Randomized Trial Comparing Adjuvant MK-3475 (Pembrolizumab) to Standard of Care Observation in Completely Resected Merkel Cell Carcinoma (NCT)Phase III Trial3/2Dr. Nasreen VohraStudy Coordinator
Leslie Corbett
corbettl@ecu.edu
744-0456
Surg Onc/Soft TissueA Phase II Randomized Study of Adjuvant Versus NeoAdjuvant MK-3475 (Pembrolizumab) for Clinically Detectable Stage III-IV High Risk MelanomaPhase II TrialClosed to enrollment
5 in follow-up		Dr. Nasreen VohraStudy Coordinator
Leslie Corbett
corbettl@ecu.edu
744-0456
TransplantTRULO - TruGraf Long-term clinical OutcomesObservationalClosed to enrollment
81 in follow-up		Dr. David LeeserStudy Coordinator
Peyton Garris
garrisp21@ecu.edu
744-0114
TransplantProActive - The PROspera Kidney Transplant ACTIVE Rejection Assessment RegistryObservationalClosed to enrollment
70 in follow-up		Dr. David LeeserStudy Coordinator
Peyton Garris
garrisp21@ecu.edu
744-0114
TransplantAPOLLO - APOL1 Long-term Kidney Transplantation Outcomes NetworkObservationalClosed to enrollment
29 enrolled		Dr. David LeeserStudy Coordinator
Peyton Garris
garrisp21@ecu.edu
744-5363
Publication Information

(January 2022-December 2022)

  1. Hao S, Parikh A, Snyder R. Defining socioeconomic disadvantage: Geography and context matter. J Surg Oncol. 2023;127(1):209-210.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. doi: 10.1002/jso.27127.

 

  1. Snyder RA. Survival benefit of neoadjuvant therapy for extrahepatic cholangiocarcinoma: Real or artifact? Ann Surg Oncol. 2023;30(1):15-17.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. doi: 10.1245/s10434-022-12352-z.

 

  1. Snyder RA, Katz MHG. Fundamentals of conducting cooperative group trials through the national clinical trials network. Surg Oncol Clin N Am. 2023;32(1):1-12.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022.  doi: 10.1016/j.soc.2022.07.002.

 

  1. Gaynor M, BeLue R, Tuttle-Newhall JE, Martin M, Patejdl F, Vogt C. Blockchain and population health. J Public Health (Oxf). 2022;44(4):e530-e536. doi: 10.1093/pubmed/fdac028.

 

  1. Burch AE, Irish WD, Wong JH. A population health assessment of screening mammography on breast cancer mortality in north carolina. Breast Cancer Res Treat. 2022;196(3):647-656.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022.  doi: 10.1007/s10549-022-06773-3.

 

  1. Burch AE, Irish WD, Wong JH. A population health assessment of screening mammography on breast cancer mortality in north carolina. Breast Cancer Res Treat. 2022;196(3):647-656.https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022.  doi: 10.1007/s10549-022-06773-3.

 

  1. Altieri MS, Pryor A, Torres MB, et al. Support of pregnancy and parental leave for trainees and practicing surgeons. Am J Surg. 2022;224(6):1501-1503.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. doi: 10.1016/j.amjsurg.2022.08.005.

 

  1. Weaver ML, Sundland R, Adams AM, et al. The art of peer review: Guidelines to become a credible and constructive peer reviewer. Semin Vasc Surg. 2022;35(4):470-478.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. doi: 10.1053/j.semvascsurg.2022.10.002.

 

  1. Oliver AL, Takahashi-Pipkin C, Wong JH, Burch AE, Irish WD. ASO visual abstract: Disparate access to surgery for operable carcinoma of the lung in north carolina. Ann Surg Oncol. 2022;29(12):7496-7497.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. doi: 10.1245/s10434-022-12275-9.

 

  1. Oliver AL, Takahashi-Pipkin C, Wong JH, Burch AE, Irish WD. Disparate access to surgery for operable carcinoma of the lung in north carolina. Ann Surg Oncol. 2022;29(12):7485-7493.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022.  doi: 10.1245/s10434-022-12101-2.

 

  1. Burch AE, Wong JH, Irish WD. ASO author reflections: Identifying and understanding disparities in access to surgery: Operable lung cancer in north carolina. Ann Surg Oncol. 2022;29(12):7494-7495.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022.  doi: 10.1245/s10434-022-12179-8.

 

  1. Oliver AL, Takahashi-Pipkin C, Wong JH, Burch AE, Irish WD. ASO visual abstract: Disparate access to surgery for operable carcinoma of the lung in north carolina. Ann Surg Oncol. 2022;29(12):7496-7497.https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022.  doi: 10.1245/s10434-022-12275-9.

 

  1. Oliver AL, Takahashi-Pipkin C, Wong JH, Burch AE, Irish WD. Disparate access to surgery for operable carcinoma of the lung in north carolina. Ann Surg Oncol. 2022;29(12):7485-7493.https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022.  doi: 10.1245/s10434-022-12101-2.

 

  1. Weaver JL, Cannada L, Anand T, et al. The importance of allyship in academic surgery. Am J Surg. 2022:S0002-X.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. doi: 10.1016/j.amjsurg.2022.10.058.

 

  1. Guetter CR, Altieri MS, Henry MCW, et al. In-person vs. virtual conferences: Lessons learned and how to take advantage of the best of both worlds. Am J Surg. 2022;224(5):1334-1336.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022.  doi: 10.1016/j.amjsurg.2022.07.016.

 

  1. Ogobuiro I, Collier AL, Khan K, et al. Racial disparity in pathologic response following neoadjuvant chemotherapy in resected pancreatic cancer: A multi-institutional analysis from the central pancreatic consortium. Ann Surg Oncol. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022&page=2.  doi: 10.1245/s10434-022-12741-4.

 

  1. Mascagni P, Alapatt D, Sestini L, et al. Computer vision in surgery: From potential to clinical value. NPJ Digit Med. 2022;5(1):163.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. doi: 10.1038/s41746-022-00707-5.

 

  1. Jog A, Altieri MS. Comment on: Outcomes of same-day discharge sleeve gastrectomy and roux-en-Y gastric bypass: A systematic review and meta-analysis. Surg Obes Relat Dis. 2022:S1550-8.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.10.013.

 

  1. Mohamed A, Kousar A, Wong J, Vohra N, Muzaffar M, Geradts J. Pathobiologic stratification of oncotype DX recurrence scores and comparative validation of 3 surrogate models. Arch Pathol Lab Med. 2022;146(10):1258-1267.https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022. Accessed Dec 15, 2022. doi: 10.5858/arpa.2021-0367-OA.

 

  1. Mohamed A, Kousar A, Wong J, Vohra N, Muzaffar M, Geradts J. Pathobiologic stratification of oncotype DX recurrence scores and comparative validation of 3 surrogate models. Arch Pathol Lab Med. 2022;146(10):1258-1267.https://pubmed.ncbi.nlm.nih.gov/?term=nasreen+vohra+2022. Accessed Dec 15, 2022. doi: 10.5858/arpa.2021-0367-OA.

 

  1. Mitsakos AT, Irish W, DeMaria EJ, Pories WJ, Altieri MS. Body mass index and risk of mortality in patients undergoing bariatric surgery. Surg Endosc. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1007/s00464-022-09651-7.

 

  1. Mitsakos AT, Irish W, DeMaria EJ, Pories WJ, Altieri MS. Body mass index and risk of mortality in patients undergoing bariatric surgery. Surg Endosc. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.1007/s00464-022-09651-7.

 

  1. Mitsakos AT, Irish W, DeMaria EJ, Pories WJ, Altieri MS. Body mass index and risk of mortality in patients undergoing bariatric surgery. Surg Endosc. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1007/s00464-022-09651-7.

 

  1. Nowicki KN, Pories WJ. Bacteria with potential: Improving outcomes through probiotic use following roux-en-Y gastric bypass. Clin Obes. 2022:e12552.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1111/cob.12552.

 

  1. Lea CS, Simeonsson K, Kipp AM, et al. Waning of SARS-CoV-2 seropositivity among healthy young adults over seven months. Vaccines (Basel). 2022;10(9):1532.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.3390/vaccines10091532.

 

  1. Snyder RA, Hu C, DiBrito SR, Chang GJ. Association of medicaid expansion with racial disparities in cancer stage at presentation. Cancer. 2022;128(18):3340-3351.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1002/cncr.34347.

 

  1. Larkins MC, Khanchandani A, Tumin D, Greene E, Ledoux M, Longshore S. Outcomes of farm compared to nonfarm pediatric injuries: A propensity-matched analysis. J Rural Health. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=shannon+longshore+2022. Accessed Dec 15, 2022. doi: 10.1111/jrh.12711.

 

  1. Snyder RA. Pas de deux. JAMA. 2022;328(9):829-830.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1001/jama.2022.14122.

 

  1. Clapp B, Ponce J, DeMaria E, et al. American society for metabolic and bariatric surgery 2020 estimate of metabolic and bariatric procedures performed in the united states. Surg Obes Relat Dis. 2022;18(9):1134-1140.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.06.284.

 

  1. Hao S, Mitsakos A, Popowicz P, Irish W, Snyder RA, Parikh AA. Differential effects of the affordable care act on the stage at presentation and receipt of treatment for pancreatic adenocarcinoma. J Surg Oncol. 2022;126(4):698-707.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1002/jso.26984.

 

  1. Hao SB, Snyder RA, Irish WD, Parikh AA. Changes in the proportion of patients presenting with early stage colon cancer over time among medicaid expansion and nonexpansion states: A cross-sectional study. Dis Colon Rectum. 2022;65(9):1084-1093.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1097/DCR.0000000000002086.

 

  1. Wercholuk AN, Parikh AA, Snyder RA. The road less traveled: Transportation barriers to cancer care delivery in the rural patient population. JCO Oncol Pract. 2022;18(9):652-662.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1200/OP.22.00122.

 

  1. Wardrop RC, Cass AL, Quinn SA, Wercholuk AN, Parikh AA, Snyder RA. Racial and ethnic differences in patient ratings of colorectal and non-small-cell lung cancer care: A SEER-CAHPS study. Cancer Causes Control. 2022;33(9):1125-1133.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1007/s10552-022-01606-6.

 

  1. Hao S, Mitsakos A, Popowicz P, Irish W, Snyder RA, Parikh AA. Differential effects of the affordable care act on the stage at presentation and receipt of treatment for pancreatic adenocarcinoma. J Surg Oncol. 2022;126(4):698-707.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022&page=2. Accessed Dec 15, 2022. doi: 10.1002/jso.26984.

 

  1. Hao SB, Snyder RA, Irish WD, Parikh AA. Changes in the proportion of patients presenting with early stage colon cancer over time among medicaid expansion and nonexpansion states: A cross-sectional study. Dis Colon Rectum. 2022;65(9):1084-1093.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022&page=2. Accessed Dec 15, 2022. doi: 10.1097/DCR.0000000000002086.

 

  1. Garfinkle R, Petersen RP, DuCoin C, et al. Consensus priority research questions in gastrointestinal and endoscopic surgery in the year 2020: Results of a SAGES delphi study. Surg Endosc. 2022;36(9):6688-6695.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1007/s00464-021-08941-w.

 

  1. Hairr M, Tumin D, Greene E, Ledoux M, Longshore S. Facility size and risk factors for mortality in pediatric trauma. Am Surg. 2022:31348221121555.https://pubmed.ncbi.nlm.nih.gov/?term=shannon+longshore+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221121555.

 

  1. Patel H, Tumin D, Greene E, Ledoux M, Longshore S. Lack of health insurance coverage and emergency medical service transport for pediatric trauma patients. J Surg Res. 2022;276:136-142.https://pubmed.ncbi.nlm.nih.gov/?term=shannon+longshore+2022. Accessed Dec 15, 2022. doi: 10.1016/j.jss.2022.02.010.

 

  1. Hao S, Mitsakos A, Irish W, Tuttle-Newhall JE, Parikh AA, Snyder RA. Differences in receipt of multimodality therapy by race, insurance status, and socioeconomic disadvantage in patients with resected pancreatic cancer. J Surg Oncol. 2022;126(2):302-313.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1002/jso.26859.

 

  1. Snyder RA, O’Reilly EM. Venous thromboprophylaxis in surgical oncology patients: The importance of risk assessment in the context of limited evidence. J Clin Oncol. 2022;40(22):2510-2511.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1200/JCO.21.02935.

 

  1. Hao S, Mitsakos A, Irish W, Tuttle-Newhall JE, Parikh AA, Snyder RA. Differences in receipt of multimodality therapy by race, insurance status, and socioeconomic disadvantage in patients with resected pancreatic cancer. J Surg Oncol. 2022;126(2):302-313.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1002/jso.26859.

 

  1. Madani A, Namazi B, Altieri MS, et al. Artificial intelligence for intraoperative guidance: Using semantic segmentation to identify surgical anatomy during laparoscopic cholecystectomy. Ann Surg. 2022;276(2):363-369.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1097/SLA.0000000000004594.

 

  1. Snyder RJ, Barrett LP. Postoccupancy evaluation of staff, visitors, and three species of animals in a zoo setting. Zoo Biol. 2022.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1002/zoo.21720.

 

  1. Snyder RA. Clinical trial eligibility criteria: A structural barrier to diversity in clinical trial enrollment. J Clin Oncol. 2022;40(20):2183-2185.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1200/JCO.22.00537.

 

  1. Singhal SK, Byun JS, Yan T, et al. Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race. JCI Insight. 2022;7(13):e157465.https://pubmed.ncbi.nlm.nih.gov/?term=nasreen+vohra+2022. Accessed Dec 15, 2022. doi: 10.1172/jci.insight.157465.

 

  1. Morton JM, Khoury H, Brethauer SA, et al. First report from the american society of metabolic and bariatric surgery closed-claims registry: Prevalence, causes, and lessons learned from bariatric surgery medical malpractice claims. Surg Obes Relat Dis. 2022;18(7):943-947.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.04.004.

 

  1. Edwards JD, Quinn SA, Saylors S, et al. Where to draw the line for intracranial hypertension; opening pressures and mortality. Am Surg. 2022;88(7):1442-1445.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221080438.

 

  1. Quinn SA, Edwards JD, Buccini P, et al. The impact of delays in interfaculty transfer on outcomes in elderly trauma patients. Am Surg. 2022;88(7):1471-1474.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221082278.

 

  1. Kusne S, Irish W, Arabia F. Extended systemic antibiotic prophylaxis in ventricular assist device recipients, an infectious disease perspective. J Card Surg. 2022;37(7):1819-1823.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022. Accessed Dec 15, 2022. doi: 10.1111/jocs.16487.

 

  1. Roll GR, Cooper M, Verbesey J, et al. Risk aversion in the use of complex kidneys in paired exchange programs: Opportunities for even more transplants? Am J Transplant. 2022;22(7):1893-1900.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1111/ajt.17008.

 

  1. Lee CE, Honaker MD. Colorectal cancer presenting as a presacral mass. Am Surg. 2022;88(7):1725-1726.https://pubmed.ncbi.nlm.nih.gov/?term=michael+honaker+2022. Accessed Dec 15, 2022. doi: 10.1177/0003134820949991.

 

  1. Roll GR, Cooper M, Verbesey J, et al. Risk aversion in the use of complex kidneys in paired exchange programs: Opportunities for even more transplants? Am J Transplant. 2022;22(7):1893-1900.https://pubmed.ncbi.nlm.nih.gov/?term=david+leeser+2022. Accessed Dec 15, 2022. doi: 10.1111/ajt.17008.

 

  1. Sheikh SS, Romine MM, Locke JE. The “broken rung” in transplantation surgery. Am J Surg. 2022;224(1 Pt A):164-165. Accessed Dec 15, 2022. doi: 10.1016/j.amjsurg.2022.02.057.

 

  1. Quinn SA, Edwards JD, Buccini P, et al. The impact of delays in interfaculty transfer on outcomes in elderly trauma patients. Am Surg. 2022;88(7):1471-1474.https://pubmed.ncbi.nlm.nih.gov/?term=kenji+leonard+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221082278.

 

  1. Edwards JD, Quinn SA, Saylors S, et al. Where to draw the line for intracranial hypertension; opening pressures and mortality. Am Surg. 2022;88(7):1442-1445.https://pubmed.ncbi.nlm.nih.gov/?term=Eric+toschlog+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221080438.

 

  1. Quinn SA, Edwards JD, Buccini P, et al. The impact of delays in interfaculty transfer on outcomes in elderly trauma patients. Am Surg. 2022;88(7):1471-1474.https://pubmed.ncbi.nlm.nih.gov/?term=Eric+toschlog+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221082278.

 

  1. Edwards JD, Quinn SA, Saylors S, et al. Where to draw the line for intracranial hypertension; opening pressures and mortality. Am Surg. 2022;88(7):1442-1445.https://pubmed.ncbi.nlm.nih.gov/?term=nicole+garcia+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348221080438.

 

  1. Altieri MS. Comment on: Patient perspectives on surgeon-specific outcome reports in bariatric surgery. Surg Obes Relat Dis. 2022;18(7):e45-e46.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.04.011.

 

  1. Snyder RA. A soft spot. J Clin Oncol. 2022;40(18):2061-2062.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1200/JCO.22.00068.

 

  1. Yaghi S, Ryan MP, Gunnarsson CL, et al. Longitudinal outcomes in cryptogenic stroke patients with and without long-term cardiac monitoring for atrial fibrillation. Heart Rhythm O2. 2022;3(3):223-230.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022. Accessed Dec 15, 2022. doi: 10.1016/j.hroo.2022.02.006.

 

  1. Jacobson SL, Puitiza A, Snyder RJ, Sheppard A, Plotnik JM. Persistence is key: Investigating innovative problem solving by asian elephants using a novel multi-access box. Anim Cogn. 2022;25(3):657-669.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1007/s10071-021-01576-3.

 

  1. Johnson HM, Torres MB, Tatebe LC, Altieri MS, from the Publications Committee of the Association of Women Surgeons. Every ounce counts: A call for comprehensive support for breastfeeding surgeons by the association of women surgeons. Am J Surg. 2022;223(6):1226-1227.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.amjsurg.2021.12.037.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Real-world retrospective analysis of outcomes in patients undergoing bariatric surgery with class 1 obesity. Surg Obes Relat Dis. 2022;18(5):569-576.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.01.011.

 

  1. Akram WM, Vohra N, Irish W, Zervos EE, Wong J. Racial disparity in the surgical management of diverticular disease. Am Surg. 2022;88(5):929-935.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211058623.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Real-world retrospective analysis of outcomes in patients undergoing bariatric surgery with class 1 obesity. Surg Obes Relat Dis. 2022;18(5):569-576.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.01.011.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Real-world retrospective analysis of outcomes in patients undergoing bariatric surgery with class 1 obesity. Surg Obes Relat Dis. 2022;18(5):569-576.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.01.011.

 

  1. Akram WM, Vohra N, Irish W, Zervos EE, Wong J. Racial disparity in the surgical management of diverticular disease. Am Surg. 2022;88(5):929-935.https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211058623.

 

  1. Akram WM, Vohra N, Irish W, Zervos EE, Wong J. Racial disparity in the surgical management of diverticular disease. Am Surg. 2022;88(5):929-935.https://pubmed.ncbi.nlm.nih.gov/?term=warqaa+akram+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211058623.

 

  1. Akram WM, Vohra N, Irish W, Zervos EE, Wong J. Racial disparity in the surgical management of diverticular disease. Am Surg. 2022;88(5):929-935.https://pubmed.ncbi.nlm.nih.gov/?term=nasreen+vohra+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211058623.

 

  1. Akram WM, Vohra N, Irish W, Zervos EE, Wong J. Racial disparity in the surgical management of diverticular disease. Am Surg. 2022;88(5):929-935.https://pubmed.ncbi.nlm.nih.gov/?term=emmanuel+zervos+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211058623.

 

  1. Poo S, Whitfield SM, Shepack A, et al. Bridging the research gap between live collections in zoos and preserved collections in natural history museums. Bioscience. 2022;72(5):449-460.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1093/biosci/biac022.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Real-world retrospective analysis of outcomes in patients undergoing bariatric surgery with class 1 obesity. Surg Obes Relat Dis. 2022;18(5):569-576.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2022.01.011.

 

  1. Altieri MS, Irish W, Pories WJ, DeMaria EJ. The US prevalence of metabolic surgery in patients with obesity and type 2 diabetes has not increased despite recommendations from the american diabetes association. Obes Surg. 2022;32(4):1086-1092.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1007/s11695-021-05865-1.

 

  1. Lim S, Hao SB, Boyd BA, et al. Opportunity costs of surgical resection and perioperative chemotherapy for locoregional pancreatic adenocarcinoma. JCO Oncol Pract. 2022;18(4):302-309.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.1200/OP.21.00311.

 

  1. Altieri MS, Irish W, Pories WJ, DeMaria EJ. The US prevalence of metabolic surgery in patients with obesity and type 2 diabetes has not increased despite recommendations from the american diabetes association. Obes Surg. 2022;32(4):1086-1092.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1007/s11695-021-05865-1.

 

  1. Altieri MS, Irish W, Pories WJ, DeMaria EJ. The US prevalence of metabolic surgery in patients with obesity and type 2 diabetes has not increased despite recommendations from the american diabetes association. Obes Surg. 2022;32(4):1086-1092.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1007/s11695-021-05865-1.

 

  1. Quinn S, Akram W, Hao S, Honaker MD. Emergency surgery for diverticulitis: Relationship of outcomes to patient age and surgical procedure. J Am Med Dir Assoc. 2022;23(4):616-622.e1.https://pubmed.ncbi.nlm.nih.gov/?term=warqaa+akram+2022. Accessed Dec 15, 2022. doi: 10.1016/j.jamda.2022.02.001.

 

  1. Quinn S, Akram W, Hao S, Honaker MD. Emergency surgery for diverticulitis: Relationship of outcomes to patient age and surgical procedure. J Am Med Dir Assoc. 2022;23(4):616-622.e1.https://pubmed.ncbi.nlm.nih.gov/?term=michael+honaker+2022. Accessed Dec 15, 2022. doi: 10.1016/j.jamda.2022.02.001.

 

  1. Mitsakos AT, Vohra NA, Fitzgerald TL, et al. Improvement in surgical quality following pancreaticoduodenectomy with increasing case volume in a rural hospital. Am Surg. 2022;88(4):746-751.https://pubmed.ncbi.nlm.nih.gov/?term=emmanuel+zervos+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211050808.

 

  1. Hao S, Reis HL, Quinn AW, Snyder RA, Parikh AA. Prehabilitation for older adults undergoing liver resection: Getting patients and surgeons up to speed. J Am Med Dir Assoc. 2022;23(4):547-554.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1016/j.jamda.2022.01.077.

 

  1. Lim S, Hao SB, Boyd BA, et al. Opportunity costs of surgical resection and perioperative chemotherapy for locoregional pancreatic adenocarcinoma. JCO Oncol Pract. 2022;18(4):302-309.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1200/OP.21.00311.

 

  1. Mitsakos AT, Vohra NA, Fitzgerald TL, et al. Improvement in surgical quality following pancreaticoduodenectomy with increasing case volume in a rural hospital. Am Surg. 2022;88(4):746-751.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1177/00031348211050808.

 

  1. Altieri MS, Irish W, Pories WJ, DeMaria EJ. The US prevalence of metabolic surgery in patients with obesity and type 2 diabetes has not increased despite recommendations from the american diabetes association. Obes Surg. 2022;32(4):1086-1092.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1007/s11695-021-05865-1.

 

  1. Samia A, Scarcella J, Zeri R, Guo Y. Intraneural synovial sarcoma of the median nerve in a 15-year-old male: A case report and review of literature. Hand (N Y). 2022;17(2):NP1-NP5. Accessed Dec 15, 2022. doi: 10.1177/1558944720975139.

 

  1. David G, Gunnarsson C, Laine L, et al. The unintended consequences of medicare’s wage index adjustment on device-intensive hospital procedures. Am J Manag Care. 2022;28(3):e96-e102.https://pubmed.ncbi.nlm.nih.gov/?term=william+irish+2022. Accessed Dec 15, 2022. doi: 10.37765/ajmc.2022.88842.

 

  1. Edwards JD, Quinn SA, Burchette M, Irish W, Poulin N, Toschlog EA. Direct peritoneal resuscitation in trauma patients results in similar rates of intra-abdominal complications. Surg Infect (Larchmt). 2022;23(2):113-118.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022. Accessed Dec 15, 2022. doi: 10.1089/sur.2021.262.

 

  1. Edwards JD, Quinn SA, Burchette M, Irish W, Poulin N, Toschlog EA. Direct peritoneal resuscitation in trauma patients results in similar rates of intra-abdominal complications. Surg Infect (Larchmt). 2022;23(2):113-118.https://pubmed.ncbi.nlm.nih.gov/?term=Eric+toschlog+2022. Accessed Dec 15, 2022. doi: 10.1089/sur.2021.262.

 

  1. Edwards JD, Quinn SA, Burchette M, Irish W, Poulin N, Toschlog EA. Direct peritoneal resuscitation in trauma patients results in similar rates of intra-abdominal complications. Surg Infect (Larchmt). 2022;23(2):113-118. Accessed Dec 15, 2022. doi: 10.1089/sur.2021.262.

 

  1. DeMaria EJ, Kothari SN, Rogers AM. VTE prevention in bariatric surgery: From where have we come, and how did we get here? Surg Obes Relat Dis. 2022;18(2):175-176.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.10.022.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Retrospective comparative study of the effectiveness of bariatric surgery on 3-year outcomes in the real-world clinical setting. Surg Obes Relat Dis. 2022;18(2):196-204.https://pubmed.ncbi.nlm.nih.gov/?term=eric+demaria+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.11.013.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Retrospective comparative study of the effectiveness of bariatric surgery on 3-year outcomes in the real-world clinical setting. Surg Obes Relat Dis. 2022;18(2):196-204.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.11.013.

 

  1. Hao S, Snyder RA, Irish W, Parikh AA. Correction: Association of race and health insurance in treatment disparities of colon cancer: A retrospective analysis utilizing a national population database in the united states. PLoS Med. 2022;19(2):e1003937.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1371/journal.pmed.1003937.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Retrospective comparative study of the effectiveness of bariatric surgery on 3-year outcomes in the real-world clinical setting. Surg Obes Relat Dis. 2022;18(2):196-204.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.11.013.

 

  1. Popowicz P, Leonard K. Noninvasive ventilation and oxygenation strategies. Surg Clin North Am. 2022;102(1):149-157.https://pubmed.ncbi.nlm.nih.gov/?term=kenji+leonard+2022. Accessed Dec 15, 2022. doi: 10.1016/j.suc.2021.09.012.

 

  1. Josef AP, Garcia NM. Systemic anticoagulation and reversal. Surg Clin North Am. 2022;102(1):53-63.https://pubmed.ncbi.nlm.nih.gov/?term=nicole+garcia+2022. Accessed Dec 15, 2022. doi: 10.1016/j.suc.2021.09.011.

 

  1. Keller DS, Snyder RA, Talimini M, et al. “How to” course for resident reviewers: From the resident and fellow education committee of the society for surgery of the alimentary tract (SSAT). J Gastrointest Surg. 2022;26(2):466-468.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1007/s11605-021-05202-y.

 

  1. Hao S, Snyder RA, Irish W, Parikh AA. Correction: Association of race and health insurance in treatment disparities of colon cancer: A retrospective analysis utilizing a national population database in the united states. PLoS Med. 2022;19(2):e1003937.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022&page=2. Accessed Dec 15, 2022. doi: 10.1371/journal.pmed.1003937.

 

  1. Altieri MS, DeMaria E, Lensing C, et al. Retrospective comparative study of the effectiveness of bariatric surgery on 3-year outcomes in the real-world clinical setting. Surg Obes Relat Dis. 2022;18(2):196-204.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.11.013.

 

  1. Aminian A, Vosburg RW, Altieri MS, Hinojosa MW, Khorgami Z, American Society for Metabolic and Bariatric Surgery Clinical Issues Committee. The american society for metabolic and bariatric surgery (ASMBS) updated position statement on perioperative venous thromboembolism prophylaxis in bariatric surgery. Surg Obes Relat Dis. 2022;18(2):165-174.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.soard.2021.10.023.

 

  1. Ieong K, Brown A, Yang J, et al. The incidence of reintervention and reoperation following heller myotomy across multiple indications. Surg Endosc. 2022;36(2):1619-1626.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1007/s00464-021-08357-6.

 

  1. Edwards JD, Flood D, McBride K, Pories W, Toschlog EA. Strangulated jejunogastric intussusception: A unique complication following billroth II reconstruction. Am Surg. 2022:31348211054530.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1177/00031348211054530.

 

  1. King WC, White GE, Belle SH, et al. Changes in smoking behavior before and after gastric bypass: A 7-year study. Ann Surg. 2022;275(1):131-139.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1097/SLA.0000000000003828.

 

  1. Chipman V, Cooper M, Thomas AG, et al. Motivations and outcomes of compatible living donor-recipient pairs in paired exchange. Am J Transplant. 2022;22(1):266-273.https://pubmed.ncbi.nlm.nih.gov/?term=david+leeser+2022. Accessed Dec 15, 2022. doi: 10.1111/ajt.16821.

 

  1. Snyder RA, Ahmad S, Katz MHG. Pancreas cancer trials for early stage disease: Surgeons leading therapeutic cooperative group trials. J Surg Oncol. 2022;125(1):75-83.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1002/jso.26701.

 

  1. Slama EM, Johnson HM, Yu YR, Sumra H, Altieri MS. Paid parental leave for surgeons in the united states. Am J Surg. 2022;223(1):218-220.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.amjsurg.2021.08.016.

 

  1. Bevilacqua LA, Siena NM, Gardner CA, Tatarian T, Madani A, Altieri MS. Gender disparities among leadership in academic surgical publishing over the past decade. Am J Surg. 2022;223(1):47-52.https://pubmed.ncbi.nlm.nih.gov/?term=maria%20altieri%202022. Accessed Dec 15, 2022. doi: 10.1016/j.amjsurg.2021.07.038.

 

  1. Mitsakos AT, Irish W, Parikh AA, Snyder RA. The association of health insurance and race with treatment and survival in patients with metastatic colorectal cancer. PLoS One. 2022;17(2):e0263818.https://pubmed.ncbi.nlm.nih.gov/?term=william%20irish%202022&page=2. Accessed Dec 15, 2022. doi: 10.1371/journal.pone.0263818.

 

  1. McLaughlin KL, Nelson MAM, Coalson HS, et al. Bioenergetic phenotyping of DEN-induced hepatocellular carcinoma reveals a link between adenylate kinase isoform expression and reduced complex I-supported respiration. Front Oncol. 2022;12:919880.https://pubmed.ncbi.nlm.nih.gov/?term=nasreen+vohra+2022. Accessed Dec 15, 2022. doi: 10.3389/fonc.2022.919880.

 

  1. Taha A, Taha-Mehlitz S, Ochs V, et al. Developing and validating a multivariable prediction model for predicting the cost of colon surgery. Front Surg. 2022;9:939079.https://pubmed.ncbi.nlm.nih.gov/?term=michael+honaker+2022. Accessed Dec 15, 2022. doi: 10.3389/fsurg.2022.939079.

 

  1. Regelsberger-Alvarez CM, Pfeifer C. Richter hernia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.http://www.ncbi.nlm.nih.gov/books/NBK537227/. Accessed Dec 15, 2022.

 

  1. Mitsakos AT, Irish W, Parikh AA, Snyder RA. The association of health insurance and race with treatment and survival in patients with metastatic colorectal cancer. PLoS One. 2022;17(2):e0263818.https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022. doi: 10.1371/journal.pone.0263818.

 

  1. Mitchell JE, Christian NJ, Flum DR, et al. Postoperative behavioral variables and weight change 3 years after bariatric surgery. JAMA Surg. 2016;151(8):752-757.https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022. doi: 10.1001/jamasurg.2016.0395.

 

  1. Body mass index and risk of mortality in patients undergoing bariatric surgery. . .https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022.

 

  1. Five-year attrition, active enrollment, and predictors of level of participation in the longitudinal assessment of bariatric surgery (LABS-2) study. . .https://pubmed.ncbi.nlm.nih.gov/?term=walter+pories+2022. Accessed Dec 15, 2022.

 

  1. ASO author reflections: Identifying and understanding disparities in access to surgery: Operable lung cancer in north carolina. . .https://pubmed.ncbi.nlm.nih.gov/?term=jan+wong+2022. Accessed Dec 15, 2022.

 

  1. Improvement in surgical quality following pancreaticoduodenectomy with increasing case volume in a rural hospital. . .https://pubmed.ncbi.nlm.nih.gov/?term=nasreen+vohra+2022. Accessed Dec 15, 2022.

 

  1. Strangulated jejunogastric intussusception: A unique complication following billroth II reconstruction. . .https://pubmed.ncbi.nlm.nih.gov/?term=Eric+toschlog+2022. Accessed Dec 15, 2022.

 

  1. Racial disparities in the management of locoregional colorectal cancer. . .https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022.

 

  1. Conservation psychology strategies for collaborative planning and impact evaluation. . .https://pubmed.ncbi.nlm.nih.gov/?term=rebecca%20snyder%202022. Accessed Dec 15, 2022.

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